为华生物胆固醇聚乙二醇活性酯CLS-PEG-NHS的简介及应用说明

胆固醇聚乙二醇活性酯CLS-PEG-NHS中活性酯在PH7-8.5与伯胺基团反应形成稳定的酰胺键。聚乙二醇增加药物溶解度和稳定性，减少多肽和蛋白质的免疫原性， 抑制带电分子在修饰表面的非特异性结合。PEG胆固醇衍生物可用于制造脂质体以改善包封药物的循环时间，它也可以用于非病毒转染试剂。

In cholesterol polyethylene glycol active ester cls-peg-nhs, the active ester reacts with the primary amine group at pH 7-8.5 to form a stable amide bond. Polyethylene glycol increases drug solubility and stability, reduces immunogenicity of peptides and proteins, and inhibits non-specific binding of charged molecules on modified surfaces. Peg cholesterol derivatives can be used to manufacture liposomes to improve the circulation time of encapsulated drugs, and it can also be used for non viral transfection reagents

目前修饰性PEG在活性化合物的配体研究,多肽合成载体,高分子接枝化合物,新型材料的PEG涂层及修饰功能化方面的应用已经成为研究趋势。

注意事项：胆固醇聚乙二醇活性酯CHOL/CLS-PEG-NHS易吸潮，取用前需放置室温后再打开包装取用防止吸潮，吸潮后活性会降低直至完全失去活性，请务必保持干燥，同时尽量避免频繁的溶解和冻干。

胆固醇-聚乙二醇-巯基，Cholesterol-PEG-Thiol，CLS-PEG-SH

胆固醇-聚乙二醇-叠氮，Cholesterol-PEG-Azide，CLS-PEG-N3

胆固醇-聚乙二醇-活性酯，Cholesterol-PEG-NHS，NHS-PEG-CLS

胆固醇-聚乙二醇-氨基，Cholesterol-PEG-Amine，CLS-PEG-NH2

胆固醇-聚乙二醇-荧光素，Cholesterol-PEG-Fluorescein，FITC-PEG-CLS

胆固醇-聚乙二醇-羧基，Cholesterol-PEG-Acid，Cholesterol-PEG-COOH

胆固醇-聚乙二醇-二苯基环辛炔，Cholesterol-PEG-DBCO，CLS-PEG-DBCO

胆固醇-聚乙二醇-马来酰亚胺，Cholesterol-PEG-Maleimide，CLS-PEG-MAL

胆固醇-甲氧基聚乙二醇 CHOL-MPEG

胆固醇-氨基 CLS-NH2

胆固醇-聚乙二醇-氨基 CHOL-PEG-NH2

胆固醇-聚乙二醇-琥珀酰亚胺酯 CHOL-PEG-NHS

胆固醇-聚乙二醇-马来酰亚胺 CHOL-PEG-Mal

胆固醇-聚乙二醇-荧光素 CHOL-PEG-FITC

胆固醇-聚乙二醇-叶酸 CHOL-PEG-FA

胆固醇-聚乙二醇-罗丹明 CHOL-PEG-Rhodamine

胆固醇-聚乙二醇-生物素 CHOL-PEG-Biotin

胆固醇-羧基 CLS-COOH

胆固醇-聚乙二醇-羟基 CHOL-PEG-OH

胆固醇-聚乙二醇-巯基 CHOL-PEG-SH

胆固醇-聚乙二醇-羧基 CHOL-PEG-COOH