氨基封端的聚乳酸羟基乙酸共聚物（PLGA-胺，PLGA-NH2，NH2-PLGA）可用于通过羧基（-COOH）或其他胺反应性化学基团修饰蛋白质，肽和其他材料，是可生物降解的聚合物纳米颗粒（NPs）之一。 由于具有受控和持续释放的特性，低毒性以及与组织和细胞的生物相容性，它已被美国FDA批准用于药物输送系统；一般用于聚合物纳米粒、微球的制备；PLGA-NH2嵌段共聚物胶束是由两亲性嵌段共聚物在水中溶解后自发形成核壳结构的高分子胶束，完成对药物的增溶和包裹，其载体多为人工合成，在水性介质中热力学稳定，可以用于一些特定小分子化合物的偶联合成； 聚乙二醇化的氨基容易与琥珀酰亚胺酯（NHS），活化的羧基（-COOH），醛基和许多其他官能团反应。
Amino terminated polylactic acid glycolic acid copolymers (PLGA amine, plga-nh2, nh2-plga) can be used to modify proteins, peptides and other materials through carboxyl groups (-cooh) or other amine reactive chemical groups, and are one of the biodegradable polymer nanoparticles (NPS). Because of its controlled and sustained release characteristics, low toxicity and biocompatibility with tissues and cells, it has been approved by the US FDA for drug delivery systems; Generally used for the preparation of polymer nanoparticles and microspheres; Plga-nh2 block copolymer micelles are polymer micelles with core-shell structure formed spontaneously after amphiphilic block copolymers are dissolved in water to complete the solubilization and encapsulation of drugs. Most of the carriers are synthetic, thermodynamically stable in aqueous media, and can be used for the coupling synthesis of some specific sub compounds; Pegylated amino groups readily react with succinimide esters (NHS), activated carboxyl groups (-cooh), aldehyde groups, and many other functional groups.
温馨提示：为华生物提供的产品，仅供科研，禁止用于人体。
